RYZODEG PENFILL is a fixed-dose combination containing Insulin Degludec and Insulin Aspart Protamine. It is indicated for the treatment of diabetes mellitus. Insulin Degludec is a long-acting insulin analog, while Insulin Aspart Protamine is an intermediate-acting insulin analog. This combination provides both basal and bolus insulin coverage, offering an effective treatment option for managing blood glucose levels in diabetic patients.

• Regulation of blood glucose levels
• Management of diabetes mellitus type 1
• Control of hyperglycemia in diabetes mellitus type 2

• Hypoglycemia (low blood sugar)
• Injection site reactions
• Weight gain
• Allergic reactions
• Hypokalemia (low potassium levels)

Administer RYZODEG PENFILL subcutaneously into the thigh, upper arm, or abdomen. Rotate injection sites to prevent lipodystrophy. Dosage and administration should be individualized based on the patient's needs and blood glucose levels.

• Pregnancy - RYZODEG PENFILL should be used with caution during pregnancy. Consult your doctor for appropriate dosing adjustments.
• Alcohol - Limit alcohol intake while using this medicine to avoid complications with blood sugar control.
• Old Age - Special care should be taken while using RYZODEG PENFILL in the elderly population, as they may be more prone to hypoglycemia.
• Breast Feeding - RYZODEG PENFILL can be used during breastfeeding with close monitoring of blood sugar levels in both the mother and infant.
• Children - RYZODEG PENFILL can be used in children with diabetes under the supervision of a healthcare provider.

• Store unused cartridges in the refrigerator between 36-46°F (2-8°C) -
• Do not freeze -
• Protect from light -

• Drug-Drug - Various drugs may interact with RYZODEG PENFILL, including oral antidiabetic agents, beta-blockers, and corticosteroids. Consult your doctor for potential drug interactions.
• Drug-Food - Alcohol and certain foods may affect blood sugar levels while using RYZODEG PENFILL. Monitor your blood sugar closely and consult your healthcare provider.
• Drug-Disease - RYZODEG PENFILL should be used cautiously in patients with renal or hepatic impairment. Dosing adjustments may be necessary.

• Q. What should I do if I miss a dose of RYZODEG PENFILL?
  If you miss a dose, administer it as soon as you remember. Do not double up on doses to make up for a missed one.
• Q. Can I adjust my RYZODEG PENFILL dose on my own?
  No, the dosage of RYZODEG PENFILL should be determined and adjusted by your healthcare provider based on your blood sugar levels and individual response.
• Q. Are there any lifestyle changes I should make while using RYZODEG PENFILL?
  Maintaining a healthy diet, regular exercise, and monitoring your blood sugar levels are essential components of managing diabetes while using RYZODEG PENFILL.
• Q. What are the signs of hypoglycemia?
  Symptoms of hypoglycemia include sweating, trembling, confusion, rapid heartbeat, and dizziness. It is important to be aware of these signs and treat low blood sugar promptly.
• Q. Can RYZODEG PENFILL be used in patients with kidney disease?
  Patients with kidney disease should use RYZODEG PENFILL with caution and under the guidance of a healthcare provider, as dosing adjustments may be necessary.