Fondaparinux is an anticoagulant. It stops the action of a substance (clotting factor
Xa) from working in the blood. This prevents the formation of unwanted blood clots
(thrombosis) in the blood vessels.

Fondaparinux is used to prevent a type of blood clot called deep vein
thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism).
A DVT can occur after certain types of surgery.
 It prevents blood clot formation that may be due to orthopedic (such as hip or knee
surgery) or abdominal surgery or due to restricted movement because of an acute
illness.
Fondaparinux is also used together with warfarin (Coumadin, Jantoven) to treat
DVT, including pulmonary embolism.

Major & minor side effects for Fondaparinux
 Pale skin
 Trouble breathing
 Unusual bleeding or bruising
 Unusual tiredness or weakness
 Fever
 Nausea or Vomiting
 Bleeding gums
 Dizziness
 Sore throat
 Dry mouth
 Chills

 This medicine is known to cause severe bleeding. It is not recommended for
patients with conditions like gastrointestinal bleeding, head injury, and
patients who are about to undergo surgery.
 Concomitant administration of this medicine and other anticoagulants may
enhance the risk of bleeding. 
 Use of this medicine with spinal or epidural anesthesia or spinal puncture
may result in spinal or epidural hematomas, which may result in long-term or
permanent paralysis.
 This medicine is not recommended for Deep vein thrombosis (DVT)-
prophylaxis if the patients weigh below 50 kg due to the increased risk of
bleeding.
 This medicine should be used with caution since it may deplete the platelet
count and increase the risk of thrombocytopenia.
 This medicine is not recommended for use in patients below 18 years of age
since the safety and efficacy of use are not clinically established.